SPring-8 Structural Biology Beamlines

Division Information

Member

Japan Synchrotron Radiation Research Institute
Structural Biology Division

Name		e-mail *	PHS
Takashi KUMASAKA	Director	kumasaka	3475
Naoto YAGI	Coordinator	yagi	3852
Experimental Instrumentation Team
Kazuya HASEGAWA	Team Leader	kazuya	3595
Seiki BABA	Scientist	baba	3510
Nobuhiro MIZUNO	Scientist	nmizuno	3797
Hideo OKUMURA	Scientist	okumurah	3755
Hironori MURAKAMI	Engineer	hiromura	3364
Takuya MASUNAGA	Engineer	takuya.masunaga	3228
Integrated Structural Analysis Team
Hideki SHIGEMATSU	Scientist	shigematsu	7868
Naoki SAKAI	Scientist	nsakai	3838
Takashi KAWAMURA	Scientist	kawamura	3396
Koji KATO	Scientist	koji.kato	3955
Yuki NAKAMURA	Engineer	y-nakamu	3362
Kenichi NISHIKAWA	Staff	nishiken	3356
Fumie OGURA	Technician	fumie	7846

*followed by @spring8.or.jp.
Please see here for the Research Project Division (Life Science and Drug Discovery Group).

Activities description

The Structural Biology Division is mainly responsible for the development and maintenance of the research environment for structural biology using the high-brilliance synchrotron radiation at SPring-8. Our Division also develops the advanced research environment to promote structural biology research aimed at elucidating biological systems.
We support academic research by maintaining and upgrading the public beamlines, Structural Biology I (BL41XU: Undulator) and Structural Biology III (BL45XU: Undulator).
In addition, in order to meet the increasing needs of users and to promote the use of the beamline, we are upgrading the following items,

(1) Development of methods to automate and remotely use experiments to speed up structural decisions
(2) Development of instruments aimed at application to samples that are difficult to analyze in the past (e.g., microcrystals and ultra-high resolution structure determination)

In addition, we are conducting crystal structure analysis of proteins, metalloproteins, and viruses in the cellular signaling system as a group to advance structural biology research and develop advanced analysis methods.

Publications

Sakaniwa, K, Fujimura A., Shibata T., Shigematsu H., Ekimoto T., Yamamoto M., Ikeguchi M., Miyake K., Ohto U., Shimizu T.
TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction
Nat. Commun., 14: 164 (2023) .
長谷川和也, 熊坂崇
放射光を用いた室温シリアル結晶構造解析
日本結晶学会誌, 64(4): 294-299 (2022) .
馬場清喜, 村川武志
Humid Air and Glue-coating method（HAG法）を用いた生理学的環境での銅含有アミン酸化酵素の構造解析
日本結晶学会誌, 64(4): 285-289 (2022) .
Nishida Y., Yanagisawa S., Morita R., Shigemastu H., Shinzawa-Itoh K., Yuki H., Ogasawara S., Shimuta K., Iwamoto T., Nakabayashi C., Matsumura W., Kato H., Gopalasingam C., Nagao T., Qaqorh T., Takahashi Y., Yamazaki S., Kamiya K., Harada R., Mizuno N., Takahashi H., Akeda Y., Ohnishi M., Ishi Y., Kumasaka T., Muramoto K., Toshia T., Shiro Y., Honma T., Shigeta Y., Kubo M., Takashima S. and Y. Shintani
Identifying Antibiotics Based on Structural Differences in the Conserved Allostery from Mitochondrial Heme-copper Oxidases
Nat. Commun., 13: 7591 (2022) .
Boos J. R., Jandrain H. N., Hagiuda E., Taguchi A. T., Hasegawa K., Fedun B. L., Taylor S. J., Elad S. M., Faber S. E., Kumasaka T., Iwasaki T. and Geldenhuys W. J.
Structure and biological evaluation of Caenorhabditis elegans CISD-1/mitoNEET, a KLP-17 tail domain homologue, supports attenuation of paraquat-induced oxidative stress through a p38 MAPK-mediated antioxidant defense response
Adv. Redox Res., 6: 100048 (2022) .

> Publications View

We are developing and improving the structural biology research environment using the high-brilliance synchrotron radiation at SPring-8.

Division Information

Member

Activities description

Publications

We are developing and improving the structural biology research environment
using the high-brilliance synchrotron radiation at SPring-8.